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The following isatins are commerically available:
- 4-chloro isatin
- 5-chloro isatin
- 6-chloro isatin
- 7-chloro isatin
- 4-chloro-7-methyl isatin
- 5-chloro-7-methyl isatin
- 4,7-dichloro isatin
- 5,7-dichloro isatin
- 4-chloro-7-dimethyl isatin
- 5-chloro-7-dimethyl isatin
- 6-chloro-7-dimethyl isatin
- 5-methyl isatin
- 7-methyl isatin
- 5-methoxy isatin
Various fluoro / trifluoromethyl isatins have been manufactured
in research quantities, solications are invited.
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Further reactions of isatins and conversions to oxindoles
2-indolineone (2-oxindole) may be considered a lactam. The chemistry of
oxindole is similar to that of a typical lactam
when the chemistry of the carbonyl group is involved. Base catalyzed
reactions which involve abstractions of a proton from C-3 are extraordinarily
facile when compared to lactams in which the anions are not stabilized by the
unique structurual features of the oxindole system. There is active consideration
using isatins and oxindoles in advanced agriculutural research in fungicides,
herbicides, and insecticides. A recent U.S. patent 3,882,236 (1975) allows a
novel route to substituted oxindoles from isatins.
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