The following isatins are commerically available:

  • 4-chloro isatin
  • 5-chloro isatin
  • 6-chloro isatin
  • 7-chloro isatin
  • 4-chloro-7-methyl isatin
  • 5-chloro-7-methyl isatin
  • 4,7-dichloro isatin
  • 5,7-dichloro isatin
  • 4-chloro-7-dimethyl isatin
  • 5-chloro-7-dimethyl isatin
  • 6-chloro-7-dimethyl isatin
  • 5-methyl isatin
  • 7-methyl isatin
  • 5-methoxy isatin

Various fluoro / trifluoromethyl isatins have been manufactured in research quantities, solications are invited.

Further reactions of isatins and conversions to oxindoles

2-indolineone (2-oxindole) may be considered a lactam. The chemistry of oxindole is similar to that of a typical lactam when the chemistry of the carbonyl group is involved. Base catalyzed reactions which involve abstractions of a proton from C-3 are extraordinarily facile when compared to lactams in which the anions are not stabilized by the unique structurual features of the oxindole system. There is active consideration using isatins and oxindoles in advanced agriculutural research in fungicides, herbicides, and insecticides. A recent U.S. patent 3,882,236 (1975) allows a novel route to substituted oxindoles from isatins.

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